Calciseptin is a 60-residue protein from Dendroaspis polylepis polylepis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P22947.
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The mean pLDDT of this model is 91.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 70% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Selectively blocks the L-type calcium channel Cav1.2/CACNA1C in a use- and voltage-independent manner (PubMed:38167790). Acts as a gating-modifier toxin, likely inhibiting channel activity by stabilizing an inactivated state; notably, it does not make direct contact with the channel voltage-sensing domain, but sits on the shoulder of the pore domain, away from the permeation path (PubMed:37972591, PubMed:38167790). Potently inhibits cardiac contraction without altering the pacemaker activity in sino-atrial node cells (PubMed:38167790). In isolated preparations, abolishes contractions and produces dose-dependent relaxation in veins, arteries, and smooth muscle (PubMed:1848702,…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
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