Ribosomal protein S6 kinase beta-1 (RPS6KB1) is a 525-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P23443.
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The mean pLDDT of this model is 72.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156,…
Interacts with PPP1R9A/neurabin-1 (By similarity). Interacts with RPTOR (PubMed:12150926). Interacts with IRS1 (PubMed:18952604). Interacts with EIF3B and EIF3C (PubMed:16286006). Interacts with TRAF4 (PubMed:12801526). Interacts with POLDIP3 (PubMed:15341740). Interacts (via N-terminus) with IER5 (PubMed:26496226)
Synapse, synaptosome, Mitochondrion outer membrane, Mitochondrion, Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5WBH | X-ray | 1.75 Å | W=412-437 |
| 3WF7 | X-ray | 1.85 Å | A=78-399 |
| 3WF8 | X-ray | 1.98 Å | A=78-399 |
| 3WE4 | X-ray | 2.0 Å | A=78-399 |
| 3WF6 | X-ray | 2.03 Å | A=78-399 |
| 3WF9 | X-ray | 2.04 Å | A=78-399 |
| 3WF5 | X-ray | 2.1 Å | A=78-399 |
| 4L3J | X-ray | 2.1 Å | A=75-375 |
| 4L3L | X-ray | 2.1 Å | A=75-375 |
| 3A62 | X-ray | 2.35 Å | A=75-399 |
| 4RLO | X-ray | 2.53 Å | A/B=85-372 |
| 7N93 | X-ray | 2.74 Å | A/B=82-421 |
| 4RLP | X-ray | 2.79 Å | A=85-372 |
| 3A60 | X-ray | 2.8 Å | A/B=75-399 |
| 4L42 | X-ray | 2.8 Å | A=75-417 |
| 4L44 | X-ray | 2.9 Å | A=75-417 |
| 4L45 | X-ray | 2.9 Å | A=75-417 |
| 4L43 | X-ray | 3.0 Å | A=75-417 |
| 7N91 | X-ray | 3.0 Å | A/B=82-421 |
| 4L46 | X-ray | 3.01 Å | A=75-417 |
Showing 20 of 22 experimental structures (best resolution first).
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