5WBH: FRB domain of mTOR

Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1. Determined by X-ray diffraction at 1.75 Å resolution. Released 20 Dec 2017.

Method: X-ray diffraction
Resolution: 1.75 Å
Organism: Homo sapiens
Chains: 6
Atoms: 4,442
Mol. weight: 63.52 kDa
Released: 20 Dec 2017

Explore 5WBH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5WBH contains 30 α-helices and 0 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	2023-2035	13
α-helix	2036-2040	5
α-helix	2044-2060	17
α-helix	2065-2091	27
α-helix	2094-2112	19

Chain B: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	2023-2035	13
α-helix	2036-2041	6
α-helix	2044-2056	13
α-helix	2065-2091	27
α-helix	2094-2112	19

Chain C: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	2023-2035	13
α-helix	2036-2040	5
α-helix	2041	1
α-helix	2044-2059	16
α-helix	2065-2091	27
α-helix	2094-2112	19

Chain D: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	2023-2035	13
α-helix	2036-2040	5
α-helix	2041	1
α-helix	2044-2059	16
α-helix	2065-2091	27
α-helix	2094-2111	18

Chain E: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	2023-2035	13
α-helix	2036-2040	5
α-helix	2044-2060	17
α-helix	2065-2091	27
α-helix	2094-2114	21

Chain W: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	395-398	4
α-helix	400-403	4
α-helix	406-408	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serine/threonine-protein kinase mTOR	A, B, C, D, E	protein	102	Homo sapiens	P42345 (AlphaFold model)
Ribosomal protein S6 kinase beta-1	W	protein	26	Homo sapiens	P23443 (AlphaFold model)

Sequence of entity 1 (A, B, C, D, E), FASTA

>5WBH_1 Serine/threonine-protein kinase mTOR (chains A, B, C, D, E)
GSRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYG
RDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQSGG

Sequence of entity 2 (W), FASTA

>5WBH_2 Ribosomal protein S6 kinase beta-1 (chains W)
TYVAPSVLESVKEKFSFEPKIRSPRR

Primary citation

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Yang, H., Jiang, X., Li, B. et al. Nature (2017) 552:368-373. DOI 10.1038/nature25023 · PubMed

Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR
1NSG 2.2 Å, The structure of the immunophilin-immunosuppressant FKBP12-rapamycin complex interacting…

Browse structure collections

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