Receptor-type tyrosine-protein phosphatase delta (PTPRD) is a 1912-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P23468.
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The mean pLDDT of this model is 82.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 54% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2
Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:9624153). Interacts (via extracellular domain) with SLITRK4 (via LRR 1 and 2 repeats). Interacts with SLITRK2; induces presynaptic differentiation. Interacts (via the second immunoglobulin domain) with IL1RAPL1 (via the first immunoglobulin domain); induces pre- and postsynaptic differentiation of neurons and synapse formation. Interacts (via the…
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2YD6 | X-ray | 1.35 Å | A=21-226 |
| 6X3A | X-ray | 1.77 Å | A=607-916 |
| 2YD7 | X-ray | 1.98 Å | A/B=21-226 |
| 4RCA | X-ray | 2.99 Å | A=21-322 |
| 5WY8 | X-ray | 3.07 Å | A=21-318 |
| 5XNP | X-ray | 3.73 Å | D/E=21-320 |
| 1X5Z | NMR | A=506-607 | |
| 2DLH | NMR | A=407-514 |
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