Follicle-stimulating hormone receptor (FSHR) is a 695-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P23945.
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The mean pLDDT of this model is 81.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Mediates FSH signaling through cAMP/protein kinase A (PKA) and phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) pathways to regulate ovarian follicular development and steroidogenesis (PubMed:24058690). Has diverse extragonadal functions: signals via a GNAI2-coupled FSHR on osteoclasts and their precursors, resulting in activation of MEK/ERK, NF-kappa-B, and AKT pathways and thus increases osteoclastogenesis and bone resorption (By similarity). Regulates glucose-stimulated insulin secretion in pancreatic beta-cells in a bell curve manner, with…
Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (PubMed:24692546, PubMed:36720854). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (PubMed:17030088). Interacts with GNAS (PubMed:36720854)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4AY9 | X-ray | 2.5 Å | X/Y/Z=17-366 |
| 8I2G | EM | 2.8 Å | R=18-695 |
| 4MQW | X-ray | 2.9 Å | X/Y/Z=16-366 |
| 1XWD | X-ray | 2.92 Å | C/F=17-268 |
| 8I2H | EM | 6.0 Å | A=14-695 |
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