G1/S-specific cyclin-D1 (CCND1) is a 295-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P24385.
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The mean pLDDT of this model is 87.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:33854235, PubMed:8114739, PubMed:8302605). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Hypophosphorylates RB1 in early G(1) phase (PubMed:1827756, PubMed:1833066,…
Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex (PubMed:19237565, PubMed:8114739). The cyclin subunit imparts substrate specificity to the complex (PubMed:19237565, PubMed:20399237, PubMed:8302605, PubMed:9106657). Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase…
Nucleus, Cytoplasm, Nucleus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9CSK | X-ray | 2.25 Å | A/C=16-271 |
| 2W96 | X-ray | 2.3 Å | A=1-271 |
| 6P8E | X-ray | 2.3 Å | A=19-267 |
| 2W9Z | X-ray | 2.45 Å | A=16-271 |
| 5VZU | X-ray | 2.7 Å | E/F=279-295 |
| 2W99 | X-ray | 2.8 Å | A=1-271 |
| 6P8G | X-ray | 2.8 Å | A=19-267 |
| 2W9F | X-ray | 2.85 Å | A=1-271 |
| 6P8F | X-ray | 2.89 Å | A=19-267 |
| 6P8H | X-ray | 3.19 Å | A=19-267 |
| 9IVD | EM | 3.55 Å | E=1-295 |
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