Interleukin-4 receptor subunit alpha (IL4R) is a 825-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P24394.
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The mean pLDDT of this model is 54.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 23% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 59% |
What pLDDT means and how to read it
Receptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2
The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422). Interacts with PIK3C3 (By…
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1IAR | X-ray | 2.3 Å | B=26-232 |
| 8K4Q | X-ray | 2.59 Å | A/C=26-232 |
| 6WGL | X-ray | 2.82 Å | C=26-232 |
| 3BPL | X-ray | 2.93 Å | B=27-227 |
| 3BPO | X-ray | 3.0 Å | B=27-227 |
| 5E4E | X-ray | 3.0 Å | B=26-228 |
| 3BPN | X-ray | 3.02 Å | B=27-227 |
| 6OEL | X-ray | 3.1 Å | B=27-224 |
| 8Z8L | X-ray | 3.96 Å | B=26-232 |
| 1IRS | NMR | B=489-499 |
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