1IAR: Interleukin-4 / receptor alpha chain complex

Interleukin-4 / receptor alpha chain complex. Determined by X-ray diffraction at 2.3 Å resolution. Released 3 Mar 2000.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,795
Mol. weight: 38.73 kDa
Released: 3 Mar 2000

Explore 1IAR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1IAR contains 12 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	5-17	13
α-helix	23-26	4
β-strand	28-30	3	1
α-helix	41-59	19
α-helix	63-65	3
α-helix	70-94	25
β-strand	106-108	3	1
α-helix	109-125	17

Chain B: 6 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	3-11	9	2
β-strand	16-23	8	2
α-helix	29-32	4
β-strand	33-39	7	3
β-strand	47-49	3	3
β-strand	52-53	2	2
β-strand	58-64	7	2
β-strand	74-80	7	3
β-strand	83-90	8	3
α-helix	92-94	3
β-strand	96	1	2
α-helix	98-101	4
β-strand	102-106	5	4
β-strand	114-119	6	4
α-helix	129-131	3
β-strand	133-140	8	5
β-strand	147-152	6	5
β-strand	158-161	4	4
β-strand	172-179	8	5
α-helix	181-183	3
α-helix	187-193	7
β-strand	194-196	3	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein (interleukin-4)	A	protein	129	Homo sapiens	P05112 (AlphaFold model)
Protein (interleukin-4 receptor alpha chain)	B	protein	207	Homo sapiens	P24394 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1IAR_1 PROTEIN (INTERLEUKIN-4) (chains A)
HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHE
KDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIM
REKYSKCSS

Sequence of entity 2 (B), FASTA

>1IAR_2 PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN) (chains B)
FKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCV
CHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSN
PYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWA
QAYNTTWSEWSPSTKWHNSYREPFEQH

Primary citation

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Hage, T., Sebald, W., Reinemer, P. Cell (1999) 97:271-281. DOI 10.1016/S0092-8674(00)80736-9 · PubMed

Other PDB entries of the same protein (UniProt P05112 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2D48 1.65 Å, Crystal structure of the Interleukin-4 variant T13D
2B8X 1.7 Å, Crystal structure of the interleukin-4 variant F82D
2B8U 1.8 Å, Crystal structure of wildtype human Interleukin-4
2B8Y 1.8 Å, Crystal structure of the interleukin-4 variant T13DF82D
2B91 2.0 Å, Crystal structure of the interleukin-4 variant F82DR85A
4YDY 2.0 Å, Crystal structure of darpin 44C12V5 in complex with human il-4
1HZI 2.05 Å, Interleukin-4 mutant E9A
2B90 2.1 Å, Crystal structure of the interleukin-4 variant T13DR85A
1RCB 2.25 Å, Crystal structure of human recombinant interleukin-4 at 2.25 Å resolution
2INT 2.35 Å, Crystal structure of recombinant human interleukin-4
2B8Z 2.5 Å, Crystal structure of the interleukin-4 variant R85A
5FHX 2.55 Å, Crystal structure of codv in complex with IL4 at 2.55 ang. Resolution.

Browse structure collections

About this viewer

MolViewer shows 1IAR directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.