N-formyl peptide receptor 2 (FPR2) is a 351-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P25090.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 84.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Pattern recognition G protein-coupled receptor (GPCR) that recognizes peptides with N-terminal formyl methionine, which are derived from invading pathogens or host mitochondria as pathogen or damage-associated molecular patterns (PAMPs and DAMPs) (PubMed:1374236, PubMed:25605714, PubMed:35217703). Preferentially recognizes longer peptides or peptides with specific sequences such as the phenol-soluble modulin (PSM) family of formylated peptide toxins produced by Staphylococcus aureus (PubMed:30098280). Ligand binding causes a conformation change that triggers signaling via G(i)/GNAI1 inhibiting adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:40080544). In…
Homodimer; the homodimerization is potentiated in response to the anti-inflammatory agonist ANXA1 and inhibited upon binding of pro-inflammatory agonist serum amyloid A (PubMed:24108355). Heterodimer with FPR1; the heterodimerization with FPR1 is potentiated in response to anti-inflammatory agonists such as lipoxin A4, ANXA1 and Ac2-26 ANXA1 peptide (PubMed:24108355). Forms a complex with…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8ZBW | EM | 2.58 Å | R=19-317 |
| 6LW5 | X-ray | 2.8 Å | A=3-322 |
| 7WVX | EM | 2.8 Å | R=2-347 |
| 7T6U | EM | 2.9 Å | R=1-342 |
| 7WVV | EM | 2.9 Å | R=2-347 |
| 7T6S | EM | 3.0 Å | R=1-342 |
| 7WVY | EM | 3.0 Å | R=2-347 |
| 7T6V | EM | 3.1 Å | R=1-342 |
| 7WVW | EM | 3.1 Å | R=2-347 |
| 6OMM | EM | 3.17 Å | R=1-342 |
| 8Y62 | EM | 3.2 Å | R=1-351 |
| 8Y63 | EM | 3.2 Å | R=1-351 |
| 9JHJ | EM | 3.2 Å | R=1-351 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.