Beta-adrenergic receptor kinase 1 (GRK2) is a 689-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P25098.
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The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:14976224, PubMed:16179383, PubMed:19306925, PubMed:19715378, PubMed:21799898, PubMed:23077507, PubMed:30284927, PubMed:33859231, PubMed:39138140, PubMed:40384633). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:14976224, PubMed:16179383, PubMed:19306925, PubMed:19715378, PubMed:21799898, PubMed:23077507, PubMed:30284927, PubMed:33859231, PubMed:39138140, PubMed:40384633). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization…
Interacts with the heterodimer formed by GNB1 and GNG2 (By similarity). Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5 (PubMed:10085131). Interacts with ARRB1 (PubMed:9501202). Interacts with LPAR1 and LPAR2 (PubMed:19306925). Interacts with RALA in response to LPAR1 activation (PubMed:19306925). ADRBK1 and RALA mutually inhibit each other's…
Cytoplasm, Cell membrane, Cell projection, cilium membrane, Postsynapse, Presynapse
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3V5W | X-ray | 2.07 Å | A=1-689 |
| 5UKL | X-ray | 2.15 Å | A=30-671 |
| 5WG4 | X-ray | 2.31 Å | A=1-689 |
| 4MK0 | X-ray | 2.4 Å | A=30-668 |
| 6U7C | X-ray | 2.44 Å | A=1-689 |
| 7K7L | X-ray | 2.54 Å | A=30-668 |
| 4PNK | X-ray | 2.56 Å | A=1-689 |
| 5UKK | X-ray | 2.6 Å | A=30-671 |
| 7PWD | X-ray | 2.6 Å | A=1-689 |
| 7K7Z | X-ray | 2.61 Å | A=30-668 |
| 5UVC | X-ray | 2.65 Å | A=23-538 |
| 5UUU | X-ray | 2.7 Å | A=23-538 |
| 6C2Y | X-ray | 2.74 Å | A=1-689 |
| 3CIK | X-ray | 2.75 Å | A=1-689 |
| 3KRW | X-ray | 2.9 Å | A=2-689 |
| 5WG3 | X-ray | 2.9 Å | A=1-689 |
| 3KRX | X-ray | 3.1 Å | A=2-689 |
| 5WG5 | X-ray | 3.1 Å | A=1-689 |
| 5HE1 | X-ray | 3.15 Å | A=29-670 |
| 1BAK | NMR | A=555-670 |
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