Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and… (STP22) is a 385-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P25604.
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The mean pLDDT of this model is 80.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1
Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of STP22, VPS28, SRN2 and MVB12 in a 1:1:1:1 stoichiometry. Interacts with HSE1 and VPS27. Interacts with MVB12 and SRN2
Cytoplasm, Endosome, Late endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3R3Q | X-ray | 1.45 Å | A=1-160 |
| 1UZX | X-ray | 1.85 Å | A=1-161 |
| 3R42 | X-ray | 1.87 Å | A=1-160 |
| 2F6M | X-ray | 2.1 Å | A/C=322-385 |
| 2P22 | X-ray | 2.7 Å | A=214-385 |
| 2F66 | X-ray | 2.8 Å | A/D=322-385 |
| 2CAZ | X-ray | 3.6 Å | A/D=305-385 |
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