DnaJ homolog subfamily B member 1 (DNAJB1) is a 340-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P25685.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 82.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region (PubMed:14503850). Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877)
Interacts with DNAJC3 (PubMed:9920933). Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Interacts with BAG3 (PubMed:30559338). Interacts with TTC1 and HSP70/HSPA1A (PubMed:14503850)
Cytoplasm, Nucleus, Nucleus, nucleolus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3AGX | X-ray | 1.85 Å | A/B=161-340 |
| 3AGY | X-ray | 1.85 Å | A/B=161-340 |
| 4WB7 | X-ray | 1.9 Å | A/B=2-70 |
| 8FE2 | X-ray | 2.34 Å | A/B=2-70 |
| 9NFS | X-ray | 2.45 Å | A/B=2-70 |
| 3AGZ | X-ray | 2.51 Å | A/B=151-340 |
| 8FE5 | X-ray | 2.51 Å | A/B=2-70 |
| 7NDX | X-ray | 2.54 Å | A=157-340 |
| 2QLD | X-ray | 2.7 Å | A=158-340 |
| 8FEC | X-ray | 2.7 Å | A/B=2-70 |
| 6BYR | X-ray | 3.66 Å | A/C=2-70 |
| 6WJG | EM | 6.2 Å | A/B=2-70 |
| 6WJF | EM | 7.5 Å | A/B=2-70 |
| 1HDJ | NMR | A=1-76 | |
| 6Z5N | NMR | A=1-110 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.