Tropomodulin-1 (TMOD1) is a 359-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P28289.
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The mean pLDDT of this model is 84.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus
Binds to the N-terminus of tropomyosin and to actin. Interacts with FLII
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4PKG | X-ray | 1.8 Å | G=50-101 |
| 4Z8G | X-ray | 2.1 Å | A=163-229 |
| 4PKH | X-ray | 2.15 Å | B/E/G/J=51-101 |
| 4PKI | X-ray | 2.3 Å | G=160-349 |
| 4Z94 | X-ray | 2.4 Å | G=160-229 |
| 8F8T | EM | 3.26 Å | T=1-359 |
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