Retinoblastoma-like protein 1 (RBL1) is a 1068-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P28749.
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The mean pLDDT of this model is 71.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 26% |
What pLDDT means and how to read it
Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904)
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2 (PubMed:16360038, PubMed:17671431). The complex exists in quiescent cells where it represses cell cycle-dependent genes (PubMed:17671431). It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7SMD | X-ray | 2.15 Å | A=391-972 |
| 4YOZ | X-ray | 2.25 Å | A=391-593, A=676-972 |
| 4YOS | X-ray | 2.3 Å | A=391-599, A=781-972 |
| 4YOO | X-ray | 2.4 Å | A=391-972 |
| 9C6B | EM | 2.6 Å | D=612-687 |
| 7SME | X-ray | 2.64 Å | A=391-972 |
| 7SMC | X-ray | 2.7 Å | A/C=391-972 |
| 1H28 | X-ray | 2.8 Å | E/F=653-663 |
| 5TUV | X-ray | 2.9 Å | C/F=994-1031 |
| 7SMF | X-ray | 3.0 Å | A/C=391-972 |
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