Nitric oxide synthase 1 (Nos1) is a 1429-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29476.
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The mean pLDDT of this model is 80.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum
Homodimer (PubMed:8864115). Interacts with DLG4 (via N-terminal tandem pair of PDZ domains); the interaction possibly being prevented by the association between NOS1 and CAPON (PubMed:23300088). Forms a ternary complex with CAPON and RASD1 (PubMed:11086993). Forms a ternary complex with CAPON and SYN1 (PubMed:11867766). Interacts with ZDHHC23 (PubMed:15105416). Interacts with NOSIP; which may…
Cell membrane, sarcolemma, Cell projection, dendritic spine
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1QAU | X-ray | 1.25 Å | A=14-125 |
| 6NGM | X-ray | 1.69 Å | A/B=297-718 |
| 4FVY | X-ray | 1.7 Å | A/B=297-718 |
| 6AUS | X-ray | 1.7 Å | A/B=297-718 |
| 6AUW | X-ray | 1.7 Å | A/B=297-718 |
| 6PN5 | X-ray | 1.7 Å | A/B=297-718 |
| 7UAN | X-ray | 1.7 Å | A=297-718 |
| 3N5W | X-ray | 1.73 Å | A/B=297-718 |
| 7S3Z | X-ray | 1.73 Å | A/B=297-718 |
| 1OM4 | X-ray | 1.75 Å | A/B=297-718 |
| 5VUN | X-ray | 1.75 Å | A/B=297-718 |
| 6AUR | X-ray | 1.75 Å | A/B=297-718 |
| 6PMW | X-ray | 1.75 Å | A/B=297-718 |
| 6AUV | X-ray | 1.76 Å | A/B=297-718 |
| 6NGJ | X-ray | 1.76 Å | A/B=297-718 |
| 6NGX | X-ray | 1.77 Å | A/B=297-718 |
| 7TSD | X-ray | 1.77 Å | A=297-718 |
| 1P6K | X-ray | 1.78 Å | A/B=297-717 |
| 3N66 | X-ray | 1.78 Å | A/B=297-718 |
| 4CTV | X-ray | 1.78 Å | A/B=297-718 |
Showing 20 of 350 experimental structures (best resolution first).
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