1OM4: Nitric-oxide synthase, brain

Structure of rat neuronal nos heme domain with L-arginine bound. Determined by X-ray diffraction at 1.75 Å resolution. Released 11 Mar 2003.

Method
X-ray diffraction
Resolution
1.75 Å
Organism
Rattus norvegicus
Chains
2
Atoms
7,483
Mol. weight
100.06 kDa
Ligands
ARG, H4B, HEM, ZN
Released
11 Mar 2003

Explore 1OM4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1OM4 contains 51 α-helices and 50 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 25 β-strands

ElementResiduesLengthSheet
β-strand301-30441
β-strand30512
β-strand311-31441
α-helix316-3194
β-strand33113
α-helix351-36818
α-helix375-39117
α-helix398-41013
α-helix418-4203
β-strand425-42844
α-helix435-45016
α-helix451-4533
β-strand458-46144
α-helix463-4653
β-strand473-47425
β-strand47816
β-strand48217
β-strand484-48638
β-strand492-49438
α-helix496-4983
α-helix499-5068
β-strand51917
α-helix520-5212
β-strand522-52545
β-strand532-53435
α-helix538-5403
β-strand543-54539
α-helix554-5574
β-strand560-56239
β-strand56716
β-strand571-574410
β-strand577-579310
β-strand584-58524
β-strand589111
α-helix590-5912
α-helix592-5976
α-helix598-5992
α-helix607-6148
α-helix621-6233
α-helix625-64319
β-strand649111
α-helix651-66919
α-helix676-6794
α-helix685-6873
α-helix689-6924
β-strand69312
β-strand697112
β-strand703-705310
α-helix710-7123
Chain B: 27 helices, 25 β-strands
ElementResiduesLengthSheet
β-strand301-304413
β-strand305114
β-strand311-314413
α-helix316-3194
β-strand331112
α-helix351-36818
α-helix375-39117
α-helix398-41013
α-helix418-4203
β-strand425-428415
α-helix435-45016
α-helix451-4533
β-strand458-461415
α-helix462-4654
β-strand473-474216
β-strand478115
β-strand482117
β-strand484-486318
β-strand492-494318
α-helix496-4983
α-helix499-5079
α-helix5181
β-strand519117
α-helix520-5212
β-strand522-525416
α-helix529-5313
β-strand532-534316
α-helix535-5373
α-helix538-5403
β-strand543-545319
α-helix554-5574
β-strand560-562319
β-strand566-567215
β-strand571-574420
β-strand577-579320
β-strand584-585215
β-strand588-589221
α-helix590-5912
α-helix592-5976
α-helix598-5992
α-helix607-6137
α-helix621-6233
α-helix625-64319
β-strand648-649221
α-helix651-66919
α-helix676-6794
α-helix685-6873
α-helix689-6924
β-strand693114
β-strand69713
β-strand703-705320
α-helix710-7123

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Nitric-oxide synthase, brainA, Bprotein422Rattus norvegicusP29476 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>1OM4_1 Nitric-oxide synthase, brain (chains A, B)
CPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFP
LAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCV
GRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWN
SQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQI
PPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVR
DYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATE
SFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVW
KG

Ligands and cofactors

IDNameFormulaCopies
ARGArginineC6 H15 N4 O22
H4B5,6,7,8-tetrahydrobiopterinC9 H15 N5 O32
HEMProtoporphyrin IX containing FEC34 H32 Fe N4 O42
ZNZinc ionZn1

Water and common crystallization additives (ACT, GOL) are not listed.

Primary citation

Structure of Rat Neuronal NOS Heme Domain with L-Arginine Bound. Li, H., Martasek, P., Shimizu, H. et al. To be published.

Other PDB entries of the same protein (UniProt P29476 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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