Guanine nucleotide-binding protein subunit alpha-11 (GNA11) is a 359-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29992.
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The mean pLDDT of this model is 92.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:31073061). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:31073061). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:31073061). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:31073061). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:31073061). Signaling is mediated via phospholipase…
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (PubMed:35061538). Interacts with RGS22 (PubMed:18703424). Interacts with NTSR1 (PubMed:21725197)
Cell membrane, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8QEH | X-ray | 1.43 Å | A=36-359 |
| 8QEG | X-ray | 1.7 Å | A=36-359 |
| 9P87 | EM | 2.8 Å | A=1-359 |
| 9UCP | EM | 2.88 Å | B=335-359 |
| 7XXH | EM | 2.9 Å | A=31-359 |
| 9P86 | EM | 2.9 Å | A=1-359 |
| 9P88 | EM | 2.9 Å | A=1-359 |
| 6OIJ | EM | 3.3 Å | A=37-359 |
| 9UAP | EM | 3.62 Å | B=335-359 |
| 7TRY | EM | 3.7 Å | A=25-359 |
| 9P8A | EM | 3.7 Å | A=1-359 |
| 9P89 | EM | 3.9 Å | A=1-359 |
| 7RKF | EM | 4.0 Å | A=25-359 |
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