9P8A: PDB entry 9P8A

NTSR1-G11-NTS(8-13) GTP-Bound Complex in the Canonical, AHD Closed State 3DVA Separated 2 (C-Closed*-GTP). Determined by electron microscopy at 3.7 Å resolution. Released 25 Mar 2026.

Method: Electron microscopy
Resolution: 3.7 Å
Organism: Homo sapiens
Chains: 3
Atoms: 4,656
Mol. weight: 88.23 kDa
Ligands: GTP
Released: 25 Mar 2026

Explore 9P8A in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9P8A contains 25 α-helices and 37 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 20 helices, 9 β-strands

Element	Residues	Length	Sheet
α-helix	12-37	26
β-strand	41-44	4	1
α-helix	52-62	11
α-helix	69-96	28
α-helix	104-115	12
α-helix	118-122	5
α-helix	126-137	12
α-helix	139-146	8
α-helix	157-162	6
α-helix	164-168	5
α-helix	173-174	2
α-helix	176-181	6
β-strand	190-195	6	1
β-strand	200-205	6	1
α-helix	215-219	5
β-strand	225-226	2	1
β-strand	229-231	3	2
β-strand	238	1	3
α-helix	239	1
β-strand	246	1	3
α-helix	247-260	14
α-helix	262-264	3
β-strand	270-274	5	2
α-helix	276-283	8
α-helix	298	1
α-helix	302-314	13
β-strand	325-328	4	2
α-helix	334-343	10
α-helix	344-348	5

Chain B: 2 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	3-25	23
α-helix	30-33	4
β-strand	47-51	5	4
β-strand	58-63	6	5
β-strand	69-74	6	5
β-strand	78-83	6	5
β-strand	88-94	7	5
β-strand	102-105	4	6
β-strand	111-115	5	6
β-strand	120-125	6	6
β-strand	134-140	7	6
β-strand	146-151	6	7
β-strand	156-161	6	7
β-strand	165-170	6	7
β-strand	176-181	6	7
β-strand	187-192	6	8
β-strand	198-203	6	8
β-strand	207-212	6	8
β-strand	218-222	5	8
β-strand	229-234	6	9
β-strand	240-245	6	9
β-strand	249-254	6	9
β-strand	259-264	6	9
β-strand	276-278	3	10
β-strand	284-287	4	10
β-strand	296-298	3	10
β-strand	303-304	2	10
β-strand	315-320	6	4
β-strand	327-331	5	4
β-strand	336-339	4	4

Chain G: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	9-24	16
α-helix	30-43	14
α-helix	53-55	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Guanine nucleotide-binding protein subunit alpha-11	A	protein	359	Homo sapiens	P29992 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	protein	344	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	G	protein	71	Homo sapiens	P59768 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9P8A_1 Guanine nucleotide-binding protein subunit alpha-11 (chains A)
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMR
IIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEK
VTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVL
RVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQR
DAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV

Sequence of entity 2 (B), FASTA

>9P8A_2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains B)
PGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLA
KIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGG
LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQ
TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP
NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNV
WDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 3 (G), FASTA

>9P8A_3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains G)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Ligands and cofactors

ID	Name	Formula	Copies
GTP	Guanosine-5'-triphosphate	C10 H16 N5 O14 P3	1

Primary citation

Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity. Vo, A.A., Modak, A., Lu, S. et al. Nature (2026) 652:803-811. DOI 10.1038/s41586-026-10120-7 · PubMed

Other PDB entries of the same protein (UniProt P29992 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8QEH 1.43 Å, Crystal structure of the G11 protein heterotrimer bound to FR900359 inhibitor
8QEG 1.7 Å, Crystal structure of the G11 protein heterotrimer bound to YM-254890 inhibitor
9P87 2.8 Å, NTSR1-G11-NTS(8-13) Complex in the Canonical, AHD Partially Closed State (C-P-Closed-Apo)
9UCP 2.88 Å, cryo-EM structure of M1 muscarinic acetylcholine receptor-alpha5 helix of G11 protein…
7XXH 2.9 Å, Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11
9P86 2.9 Å, NTSR1-G11-NTS(8-13) Complex in the Canonical, AHD Open State (C-Open-Apo)
9P88 2.9 Å, NTSR1-G11-NTS(8-13) Complex in the Non-Canonical, AHD Open State (NC-Open-Apo)
6OIJ 3.3 Å, Muscarinic acetylcholine receptor 1-G11 protein complex
9UAP 3.62 Å, cryo-EM structure of ligand-free active-state M1 muscarinic acetylcholine receptor with…
7TRY 3.7 Å, Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and…
9P89 3.9 Å, NTSR1-G11-NTS(8-13) GTP-Bound Complex in the Canonical, AHD Closed State 3DVA Separated…
7RKF 4.0 Å, Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state

Browse structure collections

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