Tegument protein BKRF4 (BKRF4) is a 217-residue protein from Epstein-Barr virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P30117.
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The mean pLDDT of this model is 55.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 61% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Overcomes the host DNA damage response (DDR) triggered by double-stranded DNA breaks by binding to host histones H2A/H2B, H3/H4 and to cellular chromatin (PubMed:35870648, PubMed:36067323). Can associate with the partially unfolded nucleosomes, promoting the nucleosome disassembly (PubMed:36067323). Interferes with histone ubiquitination and recruitment of repair proteins (PubMed:29743367)
Forms a complex with the host H3/H4 dimer and histone chaperone ASF1 (PubMed:29743367, PubMed:35870648). Also forms a complex with host H2A/H2B dimer (PubMed:29743367, PubMed:35870648). Interacts (via C-terminus) with BGLF2; this interaction is important for infectious virion production (PubMed:28904200)
Virion tegument, Host nucleus, Host cytoplasm, host perinuclear region
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7WLP | X-ray | 2.29 Å | B/C/D=16-102 |
| 7VCQ | X-ray | 3.0 Å | J=48-113 |
| 7VCL | X-ray | 3.2 Å | B=48-113 |
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