Alpha-2-macroglobulin receptor-associated protein (LRPAP1) is a 357-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30533.
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The mean pLDDT of this model is 75.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 55% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway
Interacts with the LRP1/alpha-2-macroglobulin receptor heavy and light chains; the interaction is transient and coincides with a reduction of ligand binding by the receptor (PubMed:1400426, PubMed:16678114, PubMed:16938309, PubMed:1712782, PubMed:32296178, PubMed:7774585). Interacts with LRP2/glycoprotein 330 (PubMed:1400426). Interacts with LRP1B; binding is followed by internalization and…
Rough endoplasmic reticulum lumen, Endoplasmic reticulum-Golgi intermediate compartment lumen, Golgi apparatus, cis-Golgi network, Golgi apparatus lumen, Endosome lumen, Cell surface
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2FCW | X-ray | 1.26 Å | A=249-357 |
| 9QAW | EM | 3.34 Å | K/L=35-357 |
| 1LRE | NMR | A=51-131 | |
| 1NRE | NMR | A=51-131 | |
| 1OP1 | NMR | A=51-132 | |
| 1OV2 | NMR | A=35-133 | |
| 2FTU | NMR | A=240-357 | |
| 2FYL | NMR | A=51-131 | |
| 2P01 | NMR | A=35-357 | |
| 2P03 | NMR | A=35-357 |
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