Neurotensin receptor type 1 (NTSR1) is a 418-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30989.
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The mean pLDDT of this model is 79.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
G protein-coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:21725197, PubMed:23140271, PubMed:8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197)
Interacts (palmitoylated form) with GNA11
Cell membrane, Membrane raft
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9P7Z | EM | 2.1 Å | R=20-418 |
| 9P80 | EM | 2.3 Å | R=20-418 |
| 7UL2 | EM | 2.4 Å | R=20-255, R=307-418 |
| 9P82 | EM | 2.4 Å | R=20-418 |
| 9P81 | EM | 2.6 Å | R=20-418 |
| 8ZYT | EM | 2.65 Å | R=1-418 |
| 8ZYU | EM | 2.65 Å | R=1-418 |
| 9P84 | EM | 2.7 Å | R=20-418 |
| 9P87 | EM | 2.8 Å | R=20-418 |
| 8ZYY | EM | 2.83 Å | R=1-418 |
| 9P86 | EM | 2.9 Å | R=20-418 |
| 9P88 | EM | 2.9 Å | R=20-418 |
| 6OS9 | EM | 3.0 Å | R=20-418 |
| 6OSA | EM | 3.0 Å | R=20-418 |
| 9P85 | EM | 3.0 Å | R=20-418 |
| 8JPF | EM | 3.02 Å | R=1-418 |
| 8JPB | EM | 3.07 Å | R=1-418 |
| 8JPC | EM | 3.07 Å | R=1-418 |
| 9P83 | EM | 3.2 Å | R=20-418 |
| 9M0D | EM | 3.41 Å | R=1-418 |
Showing 20 of 24 experimental structures (best resolution first).
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