Neurotensin/neuromedin N (NTS) is a 170-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30990.
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The mean pLDDT of this model is 61.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 51% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle
Interacts with NTSR1 (PubMed:23140271). Interacts with SORT1 (PubMed:19122660). Interacts with SORL1 (PubMed:11294867)
Secreted, Cytoplasmic vesicle, secretory vesicle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8VJY | X-ray | 1.95 Å | B/D=151-163 |
| 3F6K | X-ray | 2.0 Å | N=151-163 |
| 4PO7 | X-ray | 2.66 Å | N/P=151-163 |
| 5LUZ | X-ray | 2.7 Å | C/D/P/Q=151-163 |
| 6UP7 | EM | 4.2 Å | C=158-163 |
| 2LNE | NMR | A=151-163 | |
| 2LNF | NMR | A=151-163 | |
| 2LNG | NMR | A=151-163 | |
| 2LYW | NMR | B=151-163 | |
| 2OYV | NMR | A=151-163 | |
| 2OYW | NMR | A=151-163 |
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