Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) is a 252-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P33316.
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The mean pLDDT of this model is 74.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 26% |
What pLDDT means and how to read it
Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity)
Homotrimer
Nucleus, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3ARA | X-ray | 1.7 Å | A/B/C=94-252 |
| 3ARN | X-ray | 1.8 Å | A/B/C=94-252 |
| 3EHW | X-ray | 1.8 Å | A/B/C/X/Y/Z=94-252 |
| 5H4J | X-ray | 1.8 Å | A=94-252 |
| 4MZ6 | X-ray | 1.88 Å | A/C=97-109 |
| 7PWJ | X-ray | 1.94 Å | AAA/BBB/DDD=111-252 |
| 1Q5H | X-ray | 2.0 Å | A/B/C=112-252 |
| 1Q5U | X-ray | 2.0 Å | X/Y/Z=112-252 |
| 24OK | X-ray | 2.01 Å | A=70-252 |
| 4MZ5 | X-ray | 2.1 Å | A/C=97-109 |
| 2HQU | X-ray | 2.2 Å | A/B/C=94-252 |
| 8C8I | X-ray | 3.2 Å | A/B/C=112-239 |
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