Nucleoporin NIC96 (NIC96) is a 839-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P34077.
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The mean pLDDT of this model is 80.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NIC96, which is localized to the core of the NPC and the distal ring of the nuclear basket, is required for de novo assembly of NPCs. It is involved in nuclear GSP1 import
Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold…
Nucleus, nuclear pore complex, Nucleus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6X07 | X-ray | 2.1 Å | A=186-839 |
| 2QX5 | X-ray | 2.5 Å | A/B=186-839 |
| 2RFO | X-ray | 2.6 Å | A/B=189-839 |
| 7WOO | EM | 3.71 Å | A/Z=1-839 |
| 7WOT | EM | 3.73 Å | A/M/N/Z=1-839 |
| 8TJ5 | EM | 6.6 Å | Q/R/S/T=1-839 |
| 7N85 | EM | 7.6 Å | Q/R/S/T=1-839 |
| 7N9F | EM | 37.0 Å | Q/R/S/T=1-839 |
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