Transcription initiation factor TFIID subunit 14 (TAF14) is a 244-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35189.
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The mean pLDDT of this model is 85.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Functions as a component of the DNA-binding general transcription factor complex TFIID, the RNA polymerase II associated general transcription factor complex TFIIF, and the chromatin-remodeling complex SWI/SNF (PubMed:10788514, PubMed:12138208, PubMed:12516863, PubMed:9618449). Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation (PubMed:10788514, PubMed:12138208, PubMed:12516863, PubMed:9618449). TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction,…
The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14. TFIIF is composed of three different subunits: TFG1/RAP74, TFG2/RAP30 and TAF14. Component of the SWI/SNF global transcription activator complex. The…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7UHE | X-ray | 1.66 Å | A/C=168-243 |
| 3QRL | X-ray | 1.7 Å | A=1-137 |
| 6MIQ | X-ray | 1.75 Å | A=1-137 |
| 6MIO | X-ray | 1.85 Å | A=1-137 |
| 5D7E | X-ray | 1.9 Å | A=1-137 |
| 6MIN | X-ray | 1.9 Å | A=1-137 |
| 8U77 | X-ray | 1.93 Å | A/C/E/G=176-243 |
| 6MIP | X-ray | 2.0 Å | A=1-137 |
| 7F4A | X-ray | 2.0 Å | A=2-137 |
| 5IOK | X-ray | 2.22 Å | A=1-137 |
| 9VKW | EM | 3.13 Å | E=1-244 |
| 9UUS | EM | 3.2 Å | E=1-244 |
| 9UUO | EM | 3.68 Å | E=1-244 |
| 5SVA | EM | 15.3 Å | n=1-244 |
| 2L7E | NMR | A=1-123 | |
| 6LQZ | NMR | A=174-244 |
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