Catenin alpha-1 (CTNNA1) is a 906-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35221.
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The mean pLDDT of this model is 82.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties (PubMed:40983751). Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage…
Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin (By similarity). Component of an cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (PubMed:28051089). Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or…
Cytoplasm, cytoskeleton, Cell junction, adherens junction, Cell membrane, Cell junction, Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6V2O | X-ray | 1.27 Å | C=850-859 |
| 6V2P | X-ray | 1.3 Å | C=850-859 |
| 9BL4 | X-ray | 1.75 Å | C=850-859 |
| 9BL3 | X-ray | 2.0 Å | C=850-859 |
| 9BL2 | X-ray | 2.1 Å | C=850-859 |
| 1H6G | X-ray | 2.2 Å | A/B=377-632 |
| 4EHP | X-ray | 2.66 Å | B=277-382 |
| 7UTJ | EM | 2.77 Å | G/H/I/K/L/Z=22-906 |
| 6UPV | EM | 3.2 Å | L/M=1-906 |
| 4IGG | X-ray | 3.66 Å | A/B=82-906 |
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