Nitric oxide synthase, inducible (NOS2) is a 1153-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35228.
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The mean pLDDT of this model is 85.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the…
Homodimer (PubMed:10074942, PubMed:10409685). Interacts with NHERF1 (PubMed:12080081). Interacts with GAPDH; induced by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112). Interacts with S100A8 and S100A9 to form the iNOS-S100A8/9 transnitrosylase complex (PubMed:25417112). Interacts with SPSB1, SPSB2 and SPSB4 (PubMed:21199876). Interacts with ELOC and CUL5 in the…
Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6JWM | X-ray | 1.23 Å | B=21-27 |
| 6KEY | X-ray | 1.24 Å | B=22-30 |
| 5XN3 | X-ray | 1.34 Å | B=23-28 |
| 6JWN | X-ray | 1.61 Å | B/D=21-29 |
| 3E7G | X-ray | 2.2 Å | A/B/C/D=82-505 |
| 4NOS | X-ray | 2.25 Å | A/B/C/D=82-508 |
| 3HR4 | X-ray | 2.5 Å | A/C/E/G=503-715 |
| 1NSI | X-ray | 2.55 Å | A/B/C/D=74-504 |
| 3EJ8 | X-ray | 2.55 Å | A/B/C/D=82-505 |
| 2NSI | X-ray | 3.0 Å | A/B/C/D=74-504 |
| 4CX7 | X-ray | 3.16 Å | A/B/C/D=74-504 |
| 2LL6 | NMR | B=515-531 | |
| 5TP6 | NMR | B=507-531 |
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