Myosin-9 (MYH9) is a 1960-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35579.
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The mean pLDDT of this model is 76.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 16% |
| 70 to 90 | Confident: backbone generally right | 55% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411)
Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1 (By similarity). Interacts with DDR1 (By similarity). Interacts with PDLIM2 (By similarity). Interacts with SVIL (PubMed:12917436, PubMed:17925381). Interacts with HTRA3 (PubMed:22229724). Interacts with Myo7a (By…
Cytoplasm, cytoskeleton, Cytoplasm, cell cortex, Cytoplasmic vesicle, secretory vesicle, Cortical granule, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4CFQ | X-ray | 1.37 Å | Q/R=1893-1937 |
| 4CFR | X-ray | 1.4 Å | Q=1893-1937 |
| 4ETO | X-ray | 1.54 Å | P=1908-1923 |
| 3ZWH | X-ray | 1.94 Å | Q=1893-1937 |
| 9IHL | X-ray | 2.02 Å | A=1-775 |
| 9SYU | EM | 2.98 Å | A/B/G/H=1-1960 |
| 9SZR | EM | 6.3 Å | A/B=1-1960 |
| 2LNK | NMR | C=1897-1935 |
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