Epithelial sodium channel subunit alpha (SCNN1A) is a 669-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P37088.
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The mean pLDDT of this model is 74.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:8023962, PubMed:8278374, PubMed:9792722). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:24124190, PubMed:28710092, PubMed:8278374). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247). Additionally, ENaC is essential for airway surface liquid homeostasis, which is…
Heterotrimer; containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit (PubMed:30251954, PubMed:32729833). Interacts with WWP1 (via WW domains) (PubMed:9169421). Interacts with WWP2 (via WW domains); inhibits the channel (PubMed:12167593, PubMed:9169421). Interacts with BPIFA1; the interaction is indirect via SCNN1B and inhibits the proteolytic processing of SCNN1A and SCNN1G and the…
Apical cell membrane, Cell projection, cilium, Cytoplasmic granule, Cytoplasm, Cytoplasmic vesicle, secretory vesicle, acrosome, Cell projection, cilium, flagellum
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