DNA polymerase alpha subunit B (POL12) is a 705-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38121.
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The mean pLDDT of this model is 82.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Non-catalytic component of DNA polymerase alpha, which in a complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase. POL12 may play an essential role at the early stage of chromosomal DNA replication by coupling DNA polymerase alpha to the cellular replication machinery (By similarity). Interacts with MCM10
DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A POL1 and B POL12, and the DNA primase large PRI2 and small PRI1 subunits (PubMed:3061469). Subunit B POL12 binds to subunit A POL1 (PubMed:19494830)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3FLO | X-ray | 2.5 Å | A/C/E/G=246-705 |
| 8B9A | EM | 3.5 Å | B=1-705 |
| 8B9B | EM | 3.5 Å | B=1-705 |
| 8FOK | EM | 3.56 Å | C=1-705 |
| 8FOC | EM | 3.7 Å | C=1-705 |
| 8FOD | EM | 3.8 Å | C=1-705 |
| 8B9C | EM | 4.6 Å | B=1-705 |
| 8FOJ | EM | 4.8 Å | C=1-705 |
| 8FOH | EM | 4.93 Å | C=1-705 |
| 8FOE | EM | 5.6 Å | C=1-705 |
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