Autophagy-related protein 8 (ATG8) is a 117-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38182.
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The mean pLDDT of this model is 94.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosome formation (PubMed:10525546, PubMed:10681575, PubMed:10837468, PubMed:11038174, PubMed:11149920, PubMed:16680092, PubMed:18508918, PubMed:19398890, PubMed:21429936, PubMed:7593182, PubMed:8224160). With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton (PubMed:9649430). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and…
Conjugation to phosphatidylethanolamine (PE) leads to homodimerization (PubMed:17632063, PubMed:19285500, PubMed:20615880, PubMed:22539722). Interacts with ATG1 (PubMed:22778255, PubMed:22885598). Interacts with ATG3 (PubMed:11100732, PubMed:19285500, PubMed:20615880, PubMed:22539722). Interacts with ATG4 (PubMed:16680092, PubMed:9649430). Interacts with ATG7 (PubMed:11100732, PubMed:11139573,…
Cytoplasmic vesicle, cvt vesicle membrane, Cytoplasmic vesicle, autophagosome membrane, Vacuole membrane, Mitochondrion membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6WY6 | X-ray | 1.77 Å | A/B=1-116 |
| 3RUI | X-ray | 1.91 Å | B=1-116 |
| 3VH3 | X-ray | 2.0 Å | B=1-116 |
| 5YEC | X-ray | 2.15 Å | B/D=1-116 |
| 7BRN | X-ray | 2.23 Å | A=1-116 |
| 6AAG | X-ray | 2.44 Å | A/B/C/D/E/F/G=1-116 |
| 3VH4 | X-ray | 2.65 Å | B=1-116 |
| 2ZPN | X-ray | 2.7 Å | A/B/C/D=1-116 |
| 3VXW | X-ray | 3.0 Å | A=1-116 |
| 2KQ7 | NMR | A=1-117 | |
| 2KWC | NMR | A=1-116 | |
| 2LI5 | NMR | A=1-116 |
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