Inner kinetochore subunit IML3 (IML3) is a 245-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38265.
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The mean pLDDT of this model is 88.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 70% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly
Forms a heterodimer with IML3 (PubMed:12589047, PubMed:24075991). CHL4-IML3 is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). Interacts with CHL4 and…
Nucleus, Chromosome, centromere, kinetochore
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4JE3 | X-ray | 2.28 Å | A=1-242 |
| 4IT3 | X-ray | 2.5 Å | A=1-245 |
| 4KR1 | X-ray | 2.5 Å | A=1-245 |
| 8OVW | EM | 3.4 Å | L=1-245 |
| 8OW0 | EM | 3.4 Å | L=1-245 |
| 6QLF | EM | 3.45 Å | L=1-245 |
| 6QLE | EM | 3.55 Å | L=1-245 |
| 8OW1 | EM | 3.7 Å | L/LL=1-245 |
| 6QLD | EM | 4.15 Å | L=2-242 |
| 6NUW | EM | 4.25 Å | B=1-245 |
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