Integrin alpha-E (ITGAE) is a 1179-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38570.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 80.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 46% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Integrin ITGAE/ITGB7 (alpha-E/beta-7) is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers
Heterodimer of an alpha and a beta subunit (PubMed:1542691, PubMed:38781659). ITGAE/alpha-E associates with ITGB7/beta-7 (PubMed:1542691, PubMed:38781659). In the absence of the E-cadherin ligand, the heterodimer shows an overall half-bent conformation, an intermediate between closed and open conformations, with the alpha-I domain of ITGAE/alpha-E, which is responsible for ligand binding,…
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8ZJF | EM | 2.7 Å | A=2-1179 |
| 9P97 | EM | 2.92 Å | A=1-1123 |
| 9P98 | EM | 2.93 Å | A=1-1123 |
| 9P99 | EM | 3.37 Å | A=1-1123 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.