Nitrogen permease regulator 2 (NPR2) is a 615-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P39923.
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The mean pLDDT of this model is 70.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis (PubMed:21454883). Mediates inactivation of the TORC1 complex in response to amino acid starvation (PubMed:19521502, PubMed:26510498). Post-transcriptional regulator of nitrogen permeases (PubMed:19521502). May be involved in putative NPR1-dependent phosphorylation of nitrogen permeases or in the processing and targeting of nitrogen permeases at the level of the endoplasmic reticulum (PubMed:19521502)
Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1. Forms a heterodimer with NPR3
Vacuole membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8AE6 | EM | 2.7 Å | S=1-615 |
| 8ADL | EM | 2.95 Å | S/T=1-615 |
| 9H4Q | EM | 3.1 Å | T=1-615 |
| 9H5K | EM | 3.2 Å | T/g=1-615 |
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