Delta-type opioid receptor (OPRD1) is a 372-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41143.
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The mean pLDDT of this model is 80.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine
May form homooligomers. Forms a heterodimer with OPRM1 (By similarity). Interacts with GPRASP1 (PubMed:12142540, PubMed:15086532). Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4N6H | X-ray | 1.8 Å | A=36-338 |
| 9YDP | EM | 1.95 Å | R=2-372 |
| 9CGK | EM | 2.62 Å | A=38-338 |
| 4RWD | X-ray | 2.7 Å | A/B=39-338 |
| 6PT2 | X-ray | 2.8 Å | A/B=41-338 |
| 9CGJ | EM | 2.8 Å | A=38-338 |
| 8Y71 | EM | 2.97 Å | R=2-366 |
| 8F7S | EM | 3.0 Å | D/R=2-372 |
| 9PPX | EM | 3.04 Å | A=38-338 |
| 9PPY | EM | 3.1 Å | A=38-338 |
| 9PQ0 | EM | 3.12 Å | A=38-338 |
| 9PPZ | EM | 3.19 Å | A=38-338 |
| 4RWA | X-ray | 3.28 Å | A/B=39-338 |
| 6PT3 | X-ray | 3.3 Å | A/B=41-338 |
| 9PPW | EM | 3.32 Å | A=38-338 |
| 8Y45 | EM | 3.45 Å | A=36-352 |
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