Kappa-type opioid receptor (OPRK1) is a 380-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41145.
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The mean pLDDT of this model is 79.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in…
Interacts with NHERF1. Interacts with GABARAPL1
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7UL2 | EM | 2.4 Å | R=246-277 |
| 22ES | EM | 2.43 Å | R=3-380 |
| 7T10 | EM | 2.5 Å | R=256-270 |
| 8FEG | EM | 2.54 Å | B=54-358 |
| 8DZR | EM | 2.61 Å | A=54-338 |
| 8DZS | EM | 2.65 Å | A=54-358 |
| 7T11 | EM | 2.7 Å | R=256-270 |
| 8DZP | EM | 2.71 Å | A=54-358 |
| 9V6O | EM | 2.76 Å | R=54-380 |
| 8DZQ | EM | 2.82 Å | A=54-358 |
| 22EM | EM | 2.86 Å | F=54-358 |
| 4DJH | X-ray | 2.9 Å | A/B=43-358 |
| 9L60 | EM | 2.9 Å | D=3-380 |
| 9W49 | EM | 2.9 Å | R=54-358 |
| 9MQL | EM | 2.96 Å | A=1-380 |
| 7UL3 | EM | 3.0 Å | A=246-284 |
| 8K2W | EM | 3.0 Å | R=252-276 |
| 8VVF | EM | 3.0 Å | A=1-380 |
| 6B73 | X-ray | 3.1 Å | A/B=54-358 |
| 7UL5 | EM | 3.1 Å | A=256-271 |
Showing 20 of 30 experimental structures (best resolution first).
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