5-hydroxytryptamine receptor 2B (HTR2B) is a 481-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41595.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 71.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:18703043, PubMed:23519210, PubMed:7926008, PubMed:8078486, PubMed:8143856, PubMed:8882600). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538, PubMed:30127358, PubMed:36087581, PubMed:7926008, PubMed:8078486, PubMed:8143856). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:23519215, PubMed:28129538, PubMed:8078486, PubMed:8143856,…
Interacts (via C-terminus) with MPDZ
Cell membrane, Synapse, synaptosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4IB4 | X-ray | 2.7 Å | A=36-248, A=314-405 |
| 7SRQ | EM | 2.7 Å | R=36-405 |
| 4NC3 | X-ray | 2.8 Å | A=36-248, A=314-405 |
| 5TVN | X-ray | 2.9 Å | A=41-248, A=313-400 |
| 7SRR | EM | 2.9 Å | R=36-405 |
| 6DRY | X-ray | 2.92 Å | A=36-248, A=313-404 |
| 5TUD | X-ray | 3.0 Å | A/D=36-248, A/D=314-405 |
| 6DRX | X-ray | 3.1 Å | A=36-248, A=314-404 |
| 6DRZ | X-ray | 3.1 Å | A=36-248, A=313-404 |
| 6DS0 | X-ray | 3.19 Å | A=36-248, A=314-404 |
| 7SRS | EM | 3.3 Å | R=36-464 |
| 9JGK | EM | 3.6 Å | A=36-405 |
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