Protein kinase C iota type (PRKCI) is a 596-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41743.
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The mean pLDDT of this model is 80.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 34% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the…
Forms a complex with SQSTM1 and MP2K5 (By similarity). Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts with PARD6A, PARD6B and PARD6G. Part of a quaternary complex containing aPKC, PARD3, a PARD6 protein (PARD6A, PARD6B or PARD6G) and a GTPase protein (CDC42 or RAC1). Part of a complex with LLGL1 and PARD6B. Interacts with ADAP1/CENTA1. Interaction with SMG1, through…
Cytoplasm, Membrane, Endosome, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1WMH | X-ray | 1.5 Å | A=25-108 |
| 5LI9 | X-ray | 1.79 Å | A=248-596 |
| 3A8X | X-ray | 2.0 Å | A/B=249-588 |
| 5LI1 | X-ray | 2.0 Å | A=248-596 |
| 3A8W | X-ray | 2.1 Å | A/B=249-588 |
| 8R3X | X-ray | 2.59 Å | A/B=241-596 |
| 3ZH8 | X-ray | 2.74 Å | A/B/C=248-596 |
| 1ZRZ | X-ray | 3.0 Å | A=233-596 |
| 9EJK | EM | 3.08 Å | B=1-596 |
| 5LIH | X-ray | 3.25 Å | A/B=248-596 |
| 6ILZ | X-ray | 3.26 Å | A/C/E/G=249-588 |
| 9EJM | EM | 3.33 Å | B=1-596 |
| 9EJL | EM | 3.48 Å | B=1-596 |
| 8R3Y | EM | 3.68 Å | I=248-585 |
| 1VD2 | NMR | A=25-108 |
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