T-lymphocyte activation antigen CD86 (CD86) is a 329-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P42081.
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The mean pLDDT of this model is 80.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:12196291, PubMed:7694363). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291, PubMed:7694363). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the…
Homodimer (PubMed:12606712). Interacts with MARCH8 (PubMed:12582153). Interacts (via cytoplasmic domain) with PHB1 and PHB2; the interactions increases after priming with CD40 (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5YXK | X-ray | 1.9 Å | A/B/C/D=26-134 |
| 1NCN | X-ray | 2.7 Å | A/B=26-134 |
| 8HXB | EM | 2.7 Å | G/H/I/J/K/L=26-238 |
| 8HXC | EM | 3.12 Å | H/I/J/K/L/M/N=26-238 |
| 1I85 | X-ray | 3.2 Å | A/B=26-134 |
| 8FXX | EM | 3.26 Å | C/E/G/H/J/L/N=26-134 |
| 8FXY | EM | 3.34 Å | C/E/G/H/J/L=26-243 |
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