Caspase-2 (CASP2) is a 452-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P42575.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 78.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321)
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit (PubMed:12920126). Forms a complex named the PIDDosome with PIDD1 and CRADD (PubMed:15073321, PubMed:16652156, PubMed:8985253, PubMed:9044836). Interacts with NOL3 (via CARD domain); inhibits CASP2 activity in a phosphorylation-dependent manner (PubMed:9560245)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Y8D | X-ray | 1.51 Å | B=161-168 |
| 8VP4 | X-ray | 1.51 Å | A/B=93-170, A/B=176-333 |
| 6Y8B | X-ray | 1.54 Å | P=136-143 |
| 6S9K | X-ray | 1.6 Å | B=135-168 |
| 1PYO | X-ray | 1.65 Å | A/C=167-333, B/D=348-452 |
| 3R5J | X-ray | 1.77 Å | A/C=175-333, B/D=349-452 |
| 3R7B | X-ray | 1.8 Å | A/C=175-333, B/D=349-452 |
| 3R6L | X-ray | 1.9 Å | A/C=175-333, B/D=349-452 |
| 9C2Y | X-ray | 1.96 Å | A/B/C/D=93-170, A/B/C/D=177-333 |
| 3R6G | X-ray | 2.07 Å | A/C=175-333, B/D=349-452 |
| 3R7S | X-ray | 2.25 Å | A/C=175-333, B/D=349-452 |
| 3R7N | X-ray | 2.33 Å | A/C=175-333, B/D=349-452 |
| 3RJM | X-ray | 2.55 Å | A/C=167-333, B/D=348-452 |
| 6GKF | X-ray | 2.6 Å | I/J/K/L/M/N/O/P=136-143 |
| 6SAD | X-ray | 2.75 Å | C=135-168 |
| 6GKG | X-ray | 2.85 Å | I/J/K/L/M/N=161-168 |
| 2P2C | X-ray | 3.24 Å | A/C/E/G/I/K=167-333, B/D/F/H/J/L=348-452 |
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