Leukemia inhibitory factor receptor (LIFR) is a 1097-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P42702.
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The mean pLDDT of this model is 73.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Functions as a membrane-bound signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR (PubMed:11285233, PubMed:11294841, PubMed:1542794, PubMed:39532904, PubMed:9030543, PubMed:9188471). Signal transmission is initiated either by binding directly to cytokines, such as OSM or LIF or CTF1, or through the binding of other cytokines, like CNTF, CLCF1 or the heterodimeric complex CRLF1-CLCF1 to the non-signaling receptor CNTFR; ligand binding induces heterodimerization of IL6ST/gp130 and LIFR which activates JAK tyrosine kinases bound to their intracellular domains…
Heterodimer composed of LIFR and IL6ST (PubMed:1542794). Component of the ciliary neurotrophic factor receptor (CNTFR) complex composed of CNTFR, LIFR and IL6ST; CNTF binding to CNTFR induces heterodimerization of LIFR and IL6ST (PubMed:18775332, PubMed:36930708)
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8D74 | EM | 3.03 Å | B=45-833 |
| 3E0G | X-ray | 3.1 Å | A=52-534 |
| 8D6A | EM | 3.54 Å | B=45-833 |
| 8V2A | EM | 3.59 Å | C=45-833 |
| 8D7R | EM | 3.9 Å | B=45-833 |
| 8V29 | EM | 3.99 Å | C=45-833 |
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