Cryo-EM structure of human type I OSM receptor complex: model for assembly core region. Determined by electron microscopy at 3.59 Å resolution. Released 20 Nov 2024.
Explore 8V2A in 3D Show helices and sheets RCSB PDB PDBe
8V2A contains 19 α-helices and 33 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 35-49 | 15 | |
| α-helix | 52-62 | 11 | |
| α-helix | 68-72 | 5 | |
| α-helix | 76-77 | 2 | |
| α-helix | 84-89 | 6 | |
| α-helix | 94-116 | 23 | |
| α-helix | 120-126 | 7 | |
| α-helix | 131-157 | 27 | |
| α-helix | 184-211 | 28 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 133-137 | 5 | 1 |
| α-helix | 141 | 1 | |
| β-strand | 142-145 | 4 | 1 |
| β-strand | 157-163 | 7 | 2 |
| β-strand | 168-171 | 4 | 2 |
| β-strand | 181-183 | 3 | 1 |
| β-strand | 194-202 | 9 | 2 |
| β-strand | 205-208 | 4 | 2 |
| β-strand | 212-214 | 3 | 2 |
| α-helix | 216-219 | 4 | |
| β-strand | 220-221 | 2 | 1 |
| α-helix | 223-225 | 3 | |
| β-strand | 226-231 | 6 | 3 |
| β-strand | 240-245 | 6 | 3 |
| α-helix | 248-251 | 4 | |
| β-strand | 255-263 | 9 | 4 |
| α-helix | 269 | 1 | |
| β-strand | 270-271 | 2 | 4 |
| α-helix | 274-277 | 4 | |
| β-strand | 283-286 | 4 | 3 |
| β-strand | 294-303 | 10 | 4 |
| β-strand | 317-320 | 4 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 254-255 | 2 | 5 |
| β-strand | 259-262 | 4 | 6 |
| β-strand | 267-271 | 5 | 5 |
| α-helix | 276-277 | 2 | |
| β-strand | 279-282 | 4 | 7 |
| β-strand | 285-287 | 3 | 7 |
| β-strand | 290-291 | 2 | 5 |
| β-strand | 297-301 | 5 | 5 |
| β-strand | 314-317 | 4 | 7 |
| β-strand | 322-324 | 3 | 7 |
| β-strand | 327-330 | 4 | 6 |
| α-helix | 332-336 | 5 | |
| β-strand | 337-343 | 7 | 8 |
| β-strand | 348-354 | 7 | 8 |
| β-strand | 368-373 | 6 | 9 |
| β-strand | 379-381 | 3 | 9 |
| β-strand | 393-398 | 6 | 8 |
| α-helix | 399-400 | 2 | |
| β-strand | 405-414 | 10 | 9 |
| β-strand | 417-426 | 10 | 9 |
| α-helix | 427-429 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Oncostatin-M | A | protein | 196 | Homo sapiens | P13725 (AlphaFold model) |
| Interleukin-6 receptor subunit beta | B | protein | 625 | Homo sapiens | P40189 (AlphaFold model) |
| Leukemia inhibitory factor receptor | C | protein | 817 | Homo sapiens | P42702 (AlphaFold model) |
>8V2A_1 Oncostatin-M (chains A) AAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEE TLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILG LRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSV GRVFSKWGESPNRSRR
>8V2A_2 Interleukin-6 receptor subunit beta (chains B) ELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTII NRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKM RCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAEN ALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYR TKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITY EDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV NATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVE WTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYAD GPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTII GNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEEQK LISEEDLGGEQKLISEEDLHHHHHH
>8V2A_3 Leukemia inhibitory factor receptor (chains C) QKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALS HGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVF PHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYI DNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGH TNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETH DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQE IYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINF LCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSN KKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL SEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGIL LTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGC RNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFG KGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKS MYVVTKENSEQKLISEEDLGGEQKLISEEDLHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 4 |
Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes. Zhou, Y., Stevis, P.E., Cao, J. et al. Nat Commun (2024) 15:9776-9776. DOI 10.1038/s41467-024-54124-1 · PubMed
Other PDB entries of the same protein (UniProt P13725 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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