Troponin T, cardiac muscle (TNNT2) is a 298-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P45379.
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The mean pLDDT of this model is 78.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 26% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4Y99 | X-ray | 2.0 Å | B=193-298 |
| 1J1D | X-ray | 2.61 Å | B/E=193-298 |
| 8FMO | X-ray | 2.61 Å | B/E=193-298 |
| 8FMT | X-ray | 2.8 Å | B/E=193-298 |
| 8FMN | X-ray | 3.1 Å | B/E=193-298 |
| 8FMM | X-ray | 3.11 Å | B/E=193-298 |
| 8FMP | X-ray | 3.24 Å | B/E=193-298 |
| 8FMR | X-ray | 3.24 Å | B/E=193-298 |
| 8FMQ | X-ray | 3.25 Å | B/E=193-298 |
| 1J1E | X-ray | 3.3 Å | B/E=193-298 |
| 8FMS | X-ray | 3.44 Å | B/E=193-298 |
| 6KN8 | EM | 4.8 Å | T/a=109-282 |
| 7UTI | EM | 4.8 Å | X/Y/c/d=1-298 |
| 9MOW | EM | 4.9 Å | J/K=1-298 |
| 9MOP | EM | 5.0 Å | I/J=1-298 |
| 9MOO | EM | 5.2 Å | I/J=1-298 |
| 9MOX | EM | 5.2 Å | I/J=1-298 |
| 9MOA | EM | 5.4 Å | I/J=1-298 |
| 9MOB | EM | 5.5 Å | J/K=1-298 |
| 9MO9 | EM | 5.6 Å | I/J=1-298 |
Showing 20 of 25 experimental structures (best resolution first).
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