8FMR: Troponin C, slow skeletal and cardiac muscles
Complex structure of K210 deletion Troponin complex with ibandronate. Determined by X-ray diffraction at 3.24 Å resolution. Released 31 Jan 2024.
- Method
- X-ray diffraction
- Resolution
- 3.24 Å
- Organism
- Homo sapiens
- Chains
- 6
- Atoms
- 5,379
- Mol. weight
- 94.34 kDa
- Ligands
- CA
- Released
- 31 Jan 2024
Explore 8FMR in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8FMR contains 36 α-helices and 6 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 9 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-10 | 5 | |
| α-helix | 16-27 | 12 | |
| β-strand | 36 | 1 | 1 |
| α-helix | 38-46 | 9 | |
| α-helix | 54-61 | 8 | |
| β-strand | 72 | 1 | 1 |
| α-helix | 75-82 | 8 | |
| α-helix | 96-104 | 9 | |
| α-helix | 114-122 | 9 | |
| α-helix | 130-140 | 11 | |
| α-helix | 150-156 | 7 | |
Chain B: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 207-212 | 6 | |
| α-helix | 215-219 | 5 | |
| α-helix | 225-229 | 5 | |
| α-helix | 234-269 | 36 | |
Chain C: 6 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 45-57 | 13 | |
| α-helix | 59-62 | 4 | |
| α-helix | 67-78 | 12 | |
| α-helix | 81-83 | 3 | |
| α-helix | 94-134 | 41 | |
| α-helix | 152-155 | 4 | |
Chain D: 10 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-8 | 7 | |
| α-helix | 14-19 | 6 | |
| α-helix | 24-27 | 4 | |
| β-strand | 36 | 1 | 2 |
| α-helix | 40-48 | 9 | |
| α-helix | 54-62 | 9 | |
| β-strand | 72 | 1 | 2 |
| α-helix | 74-82 | 9 | |
| α-helix | 94-104 | 11 | |
| β-strand | 112-113 | 2 | 3 |
| α-helix | 114-122 | 9 | |
| α-helix | 130-140 | 11 | |
| β-strand | 147-148 | 2 | 3 |
| α-helix | 150-156 | 7 | |
Chain E: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 207-215 | 9 | |
| α-helix | 231-266 | 36 | |
Chain F: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 43-79 | 37 | |
| α-helix | 81-83 | 3 | |
| α-helix | 91-94 | 4 | |
| α-helix | 97-134 | 38 | |
| α-helix | 151-158 | 8 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Troponin C, slow skeletal and cardiac muscles | A, D | protein | 164 | Homo sapiens | P63316 (AlphaFold model) |
| Troponin T, cardiac muscle | B, E | protein | 108 | Homo sapiens | P45379 (AlphaFold model) |
| Troponin I, cardiac muscle | C, F | protein | 135 | Homo sapiens | P19429 (AlphaFold model) |
Sequence of entity 1 (A, D), FASTA
>8FMR_1 Troponin C, slow skeletal and cardiac muscles (chains A, D)
QGSMDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGSISTKELGKVMRMLGQNPTPEEL
QEMIDEVDEDGSGTVDFDEFLVMMVRSMKDDSKGKSEEELSDLFRMFDKNADGYIDLEEL
KIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
Sequence of entity 2 (B, E), FASTA
>8FMR_2 Troponin T, cardiac muscle (chains B, E)
QGSHFGGYIQKQAQTERKSGKRQTEREKKKILAERRKVLAIDHLNEDQLREKAKELWQSI
YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Sequence of entity 3 (C, F), FASTA
>8FMR_3 Troponin I, cardiac muscle (chains C, F)
EPHAKKKSKISASRKLQLKTLLLQIAKQELEREAEERRGEKGRALSTRAQPLELAGLGFA
ELQDLARQLHARVDKVDEERYDIEAKVTKNITEIADLTQKIFDLRGKFKRPTLRRVRISA
DAMMQALLGARAKES
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| CA | Calcium ion | Ca | 6 |
Primary citation
Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved drug. Wang, P., Ahmed, M., Sadek, H. To be published.
Other PDB entries of the same protein (UniProt P63316 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 3SD6 1.37 Å, Crystal structure of the amino-terminal domain of human cardiac troponin C in complex…
- 4GJE 1.6 Å, Crystal structure of the refolded amino-terminal domain of human cardiac troponin C in…
- 3SWB 1.67 Å, Crystal structure of the amino-terminal domain of human cardiac troponin C in complex…
- 7SC2 1.81 Å, Crystal structure of the N-domain of cardiac muscle troponin C tethered to the switch…
- 4GJF 1.9 Å, Crystal structure of the amino-terminal domain of human cardiac troponin C mutant L29Q…
- 4GJG 2.0 Å, Crystal structure of the amino-terminal domain of human cardiac troponin C mutant…
- 4Y99 2.0 Å, Core domain of human cardiac troponin
- 1WRK 2.15 Å, Crystal structure of the N-terminal domain of human cardiac troponin C in complex with…
- 3RV5 2.2 Å, Crystal structure of human cardiac troponin C regulatory domain in complex with cadmium…
- 7SC3 2.23 Å, Crystal structure of the N-domain of cardiac muscle troponin C tethered to the switch…
- 1WRL 2.6 Å, Crystal structure of the N-terminal domain of human cardiac troponin C in complex with…
- 1J1D 2.61 Å, Crystal structure of the 46kDa domain of human cardiac troponin in the Ca2+ saturated form
Browse structure collections
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