Chemerin-like receptor 2 (CMKLR2) is a 355-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P46091.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 83.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Also acts as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8JJP | EM | 2.9 Å | A=35-326 |
| 9UYN | EM | 2.9 Å | R=2-322 |
| 9UYI | EM | 3.2 Å | R=2-322 |
| 8XGM | EM | 3.29 Å | A=14-319 |
| 9UYH | EM | 3.3 Å | R=2-322 |
| 9UYJ | EM | 3.3 Å | R=2-322 |
| 9UYL | EM | 3.3 Å | R=2-322 |
| 9UYM | EM | 3.5 Å | R=2-322 |
| 9L3Y | EM | 3.6 Å | R=1-322 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.