Cyclin-dependent kinase inhibitor 1B (CDKN1B) is a 198-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P46527.
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The mean pLDDT of this model is 69.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 36% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichiometry
Forms a ternary complex composed of CCNE1, CDK2 and CDKN1B. Interacts directly with CCNE1; the interaction is inhibited by CDK2-dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome complex; the interaction leads to CDKN1B degradation. Interacts with NUP50; the interaction leads to nuclear import and degradation of phosphorylated CDKN1B. Interacts with CCND1…
Nucleus, Cytoplasm, Endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7OR8 | X-ray | 1.8 Å | P=187-198 |
| 7ORG | X-ray | 1.8 Å | P=187-198 |
| 7ORH | X-ray | 1.8 Å | P=187-198 |
| 7ORS | X-ray | 1.8 Å | P=187-198 |
| 6ATH | X-ray | 1.82 Å | C=22-85 |
| 1H27 | X-ray | 2.2 Å | E=25-35 |
| 1JSU | X-ray | 2.3 Å | C=23-106 |
| 2AST | X-ray | 2.3 Å | D=181-190 |
| 6P8E | X-ray | 2.3 Å | C=25-93 |
| 7ORT | X-ray | 2.33 Å | P=187-198 |
| 6P8G | X-ray | 2.8 Å | C=25-93 |
| 6P8F | X-ray | 2.89 Å | C=25-106 |
| 8BYA | EM | 3.38 Å | C=1-158, G=181-190 |
| 8BYL | EM | 3.5 Å | D=1-198 |
| 8BZO | EM | 3.5 Å | C=1-158 |
| 5UQ3 | X-ray | 3.6 Å | C=1-198 |
| 7B5L | EM | 3.8 Å | P=1-198 |
| 7B5R | EM | 3.8 Å | P=1-198 |
| 7B5M | EM | 3.91 Å | P=1-198 |
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