Kinesin-like protein Klp61F (Klp61F) is a 1066-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P46863.
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The mean pLDDT of this model is 74.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 58% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Important role in mitotic dividing cells (PubMed:8227131). Microtubule motor required for spindle body separation (PubMed:8918872). Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function (PubMed:19062285, PubMed:8589456, PubMed:8918872). Forms cross-links between microtubules within interpolar microtubule bundles (PubMed:19158379, PubMed:9885249). Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinetochore spacing,…
Homotetramer (PubMed:24714498, PubMed:8538794, PubMed:9885249). Consists of two pairs of polypeptides associated by coiled-coil interactions to form two homodimers (PubMed:8538794). The homodimers are linked by lateral interactions between their coiled-coil regions to form a bipolar homotetramer consisting of a central rod with two motor domains projecting from either end (PubMed:8538794).…
Cytoplasm, cytoskeleton, spindle, Cytoplasm, cytoskeleton, spindle pole, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7LXR | X-ray | 1.74 Å | A/B=1-367 |
| 4PXU | X-ray | 2.6 Å | A/B=634-839 |
| 4PXT | X-ray | 2.9 Å | A/B=634-839 |
| 6VPO | EM | 4.4 Å | C=1-369 |
| 6VPP | EM | 4.4 Å | C=1-369 |
| 7S5U | X-ray | 4.41 Å | A/B/C/D=597-835 |
| 2WBE | EM | 9.4 Å | C=1-368 |
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