Transcription factor SOX-2 (Sox2) is a 319-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48432.
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The mean pLDDT of this model is 59.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 23% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 22% |
| Below 50 | Very low: often disordered regions | 52% |
What pLDDT means and how to read it
Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739, PubMed:32703285). Binds to the proximal enhancer region of NANOG (PubMed:15863505). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch…
Interacts with ZSCAN10 (PubMed:19740739). Interacts with SOX3 and FGFR1 (PubMed:17728342). Interacts with GLIS1 (By similarity). Interacts with POU5F1; binds synergistically with POU5F1 to DNA (PubMed:15863505). Interacts with DDX56 (PubMed:32703285). Interacts with L3MBTL3 and DCAF5 (PubMed:30442713). The interaction with L3MBTL3 and DCAF5 requires methylation at Lys-44 and is necessary to…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8BX1 | X-ray | 2.5 Å | E=41-120 |
| 1GT0 | X-ray | 2.6 Å | D=41-120 |
| 8BX2 | X-ray | 3.14 Å | E=41-120 |
| 6HT5 | X-ray | 3.45 Å | D=41-120 |
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