8BX1: Oct4/Sox2 protein:DNA complex

Oct4/Sox2 protein:DNA complex. Determined by X-ray diffraction at 2.5 Å resolution. Released 20 Dec 2023.

Method
X-ray diffraction
Resolution
2.5 Å
Organism
Mus musculus
Chains
4
Atoms
2,536
Mol. weight
41.56 kDa
Released
20 Dec 2023

Explore 8BX1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8BX1 contains 13 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix-1-810
α-helix12-2211
α-helix27-3812
α-helix44-518
α-helix57-7418
α-helix104-11411
α-helix120-13011
α-helix134-14714
Chain E: 5 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix2-87
α-helix9-2416
α-helix30-4314
α-helix46-6621
α-helix74-763

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transcription factor SOX-2Eprotein83Mus musculusP48432 (AlphaFold model)
HOXB1_rDDNA22Mus musculus
HOXB1_fCDNA22Mus musculus
POU domain, class 5, transcription factor 1Aprotein155Mus musculusP20263 (AlphaFold model)
Sequence of entity 1 (E), FASTA
>8BX1_1 Transcription factor SOX-2 (chains E)
GAMDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAK
RLRALHMKEHPDYKYRPRRKTKT
Sequence of entity 2 (D), FASTA
>8BX1_2 HOXB1_r (chains D)
TAATCATTAGCATGACAAAGAC
Sequence of entity 3 (C), FASTA
>8BX1_3 HOXB1_f (chains C)
AGTCTTTGTCATGCTAATGATT
Sequence of entity 4 (A), FASTA
>8BX1_4 POU domain, class 5, transcription factor 1 (chains A)
GAMDMKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTISRFEALQLSL
KNMSKLRPLLEKWVEEADNNENLQEISKSETLVQARKRKRTSIENRVRWSLETMFLKSPK
PSLQQITHIANQLGLEKDVVRVWFSNRRQKGKRSS

Primary citation

Crystal structure of Oct4-Soc2-HoxB1 complex. Chojnowski, G., Wilmanns, M., Round, E. To be published.

Other PDB entries of the same protein (UniProt P48432 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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