Gastric inhibitory polypeptide receptor (GIPR) is a 466-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48546.
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The mean pLDDT of this model is 78.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
May form homodimers and heterodimers with GLP1R
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2QKH | X-ray | 1.9 Å | A=24-138 |
| 6DKJ | X-ray | 1.95 Å | C/D=22-138 |
| 8WA3 | EM | 2.86 Å | R=22-421 |
| 7DTY | EM | 2.98 Å | R=22-421 |
| 4HJ0 | X-ray | 3.0 Å | A/B=24-138 |
| 7RBT | EM | 3.08 Å | R=22-466 |
| 7FIN | EM | 3.1 Å | R=22-421 |
| 8ITM | EM | 3.13 Å | R=94-421 |
| 7VAB | EM | 3.2 Å | R=22-421 |
| 8ITL | EM | 3.23 Å | R=22-421 |
| 7RA3 | EM | 3.24 Å | R=22-466 |
| 8YW4 | EM | 3.26 Å | R=22-421 |
| 7FIY | EM | 3.4 Å | R=22-421 |
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